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Trefoil Therapeutics Announces the Signing of a License and Research Agreement with Florida State University for Engineered FGF-1 Derivatives

An empirical phase diagram approach to investigate conformational stability of “second-generation” functional mutants of acidic fibroblast growth factor (FGF-1), Alsenaidy, M.A., Wang, T., Kim, J.H., Joshi, S.B., Lee, J., Blaber, M., Volkin, D.B., and Middaugh, C.R., Prot. Sci. 21, 418-432 (2012) PMID: 221139

Pharmacokinetic properties of 2nd-generation fibroblast growth factor-1 mutants for therapeutic application, Xia, X., Babcock, J.P., Blaber, S.I., Harper, K.M. and Blaber, M., PLoS ONE 7(11): e48210 (2012) PMID: 23133616

Structural Basis of Conserved Cysteine in the Fibroblast Growth Factor Family: Evidence for a Vestigial Half-cystine, Lee, J. and Blaber, M., J. Mol. Biol. 393, 128-139 (2009)

The Interaction between Thermodynamic Stability and Buried Free Cysteines in Regulating the Functional Half-life of Fibroblast Growth Factor-1, Lee, J. and Blaber, M., J. Mol. Biol. 393, 113-127 (2009) PMID: 19695265

Spackling the Crack: Stabilizing Human Fibroblast Growth Factor-1 by Targeting the N- and C-terminus β-strand Interactions, Dubey, V.K., Lee, J., Somasundaram, T., Blaber, S. and Blaber, M., J. Mol. Biol. 371, 256-268 (2007)

An Atomic Resolution Structure for Human Fibroblast Growth Factor-1, Bernett, M.J., Somasundaram, T. and Blaber, M. Proteins: Structure, Function and Bioinformatics 57, 626-634 (2004)

Thermodynamic Characterization of Mutants of Human FGF-1 with an Increased Physiological Half-life, Culajay, J.F., Blaber, S.I., Khurana, A. and Blaber, M. Biochemistry 39, 7153-7158 (2000)

Reversible Thermal Denaturation of Human FGF-1 Induced by Low Concentrations of Guanidine Hydrochloride, Blaber, S.I., Culajay, J.F., Khurana, A. and Blaber, M. Biophysical Journal 77, 470-477 (1999)

X-ray Crystal Structure of Human Acidic Fibroblast Growth Factor, Blaber, M., DiSalvo, J. and Thomas, K.A. Biochemistry 35, 2086-2094 (1996)